It is commonly used to treat conditions like schizophrenia and bipolar disorder, but its calming effects make it a valuable option for anxiety management. Seroquel works by affecting neurotransmitters in the brain, helping to stabilize mood and reduce anxiety. Quetiapine (Seroquel) for Anxiety Quetiapine should not be used as a first-line treatment for anxiety disorders; SSRIs and SNRIs are the evidence-based first-line pharmacological options with superior efficacy and safety profiles. 1 Seroquel (quetiapine) may help reduce severe anxiety symptoms by balancing serotonin and dopamine levels, improving mood stability and emotional calm. It is not a first-line anxiety treatment but may be used when symptoms are intense or resistant to other therapies. Find patient medical information for Quetiapine (Seroquel) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Seroquel (quetiapine) may work for anxiety by affecting certain chemicals in the brain called neurotransmitters. It helps regulate the levels of these chemicals, like serotonin and dopamine, which play a role in mood and anxiety. Seroquel (quetiapine) is an atypical antipsychotic primarily used to treat mental disorders like depression but is also prescribed off-label for anxiety disorders. While not FDA-approved for anxiety, some doctors consider it an option when first-line anxiety treatments don’t suffice. Seroquel (quetiapine) does reduce anxiety, and at low doses it actually outperforms standard antidepressants on anxiety rating scales. But it comes with trade-offs that explain why most doctors don’t reach for it first. Several years ago, but several times, Seroquel saved me from the extreme anxiety I had from taking high dose oral steroids for breathing problems/asthma. Anxiety meds were not working, so the doctor prescribed Seroquel 25mg. Seroquel (quetiapine) is an antipsychotic sometimes prescribed off-label for anxiety. Understand how it works, typical dosing, side effects, and key cautions. Some studies have indicated the efficacy of quetiapine in the treatment of generalized anxiety disorder (GAD). The purpose of this study was to systematically review the efficacy, acceptability, and tolerability of quetiapine in adult patients with GAD.